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What is Sildenafil?

kokou adzo



sildenafil intro

Sildenafil, also known as Viagra, has transformed the way erectile dysfunction (ED) and other disorders connected to it are treated. It has shown tremendous growth in popularity as an effective erectile dysfunction medication in recent years. But it can also be used for more than that. The medicine has been a member of the group of medications known as phosphodiesterase type 5 (PDE5) inhibitors. These medications stop phosphodiesterase type-5 from functioning too quickly. One of the places where this enzyme functions is the male reproductive part. It was initially created to alleviate chest pain and excessive blood pressure but it was realised later that it had incredible impacts on the sexual functioning of men. Since being approved by the American Food and Drug Administration (FDA) in 1998, it has transformed the way that erectile dysfunction (ED) is treated.

Erectile dysfunction

Nitric oxide is released when a guy is sexually aroused and this causes the body to produce more cGMP. The smooth muscle cells lining the blood vessels in the penis loosen up when cGMP is present, enabling the blood vessels to enlarge and flow more freely. The flow of blood increases as a result of nerve impulses. The rapid input of blood that causes the penis to grow, straighten and stiffen results in an erection. The blood is trapped and the erection is maintained because the veins that typically carry blood out from the penis are restricted. aWhen there is a blockage or restriction in the blood flow to the penis, erectile dysfunction frequently results.

What is Sildenafil?

The oral drug sildenafil is used to treat erectile dysfunction in males by assisting in erection onset and maintenance. By boosting blood flow to the penis, it promotes an enjoyable sexual encounter. It is customary to take sildenafil between 30 and 60 minutes before engaging in sexual activity.

Sildenafil mechanism of action

The penis cannot stiffen into an erection or be sustained throughout a sexual experience if blood cannot flow to and from it efficiently when it is aroused. Cyclic guanosine monophosphate (cGMP) is a compound that is broken down by the enzyme PDE5, which is the main mechanism of action for sildenafil. Sildenafil increases cGMP levels by blocking PDE5, which promotes relaxation of the smooth muscles of the penis and improves blood flow to the erectile tissues.

Dosage and precaution

Sildenafil should be used as needed before sexual activity. The ideal time to take sildenafil is around an hour prior to sexual activity. You can also take the drug up to 4 hours or 30 minutes in advance. Generally speaking, sildenafil shouldn’t be used more than once per 24 hours. Typically, 50 milligrams of sildenafil should be taken as needed about an hour prior to sexual activity as the recommended starting dose. A maximum daily dose of 100 milligrams may be used, with dosage adjustments dependent on each person’s response and tolerance.

People with specific medical disorders, such as severe heart or liver issues, recent stroke or heart attack, uncontrolled low blood pressure, or severe heart or liver problems shouldn’t use sildenafil. It shouldn’t be taken alongside nitrates because the two together can cause a harmful reduction in blood pressure.

Side effects of Sildenafil

Medication may have side effects in addition to the intended benefits such as bladder discomfort searing sensation in the chest or stomach, crawling, itching, numbness, prickling, “pins and needles”-like sensations or tingling sensations nausea and vertigo hazy or crimson urine, a greater need to urinate frequently indigestion.

More severe adverse effects, like priapism (a painful erection lasting longer than four hours), unexpected vision loss and hearing loss, have only sometimes been linked to sildenafil use. In the event of any of these, get medical help right away.

After taking sildenafil or other drugs that are similar to sildenafil, some individuals suffer an abrupt decline or loss of hearing. It is unknown if the drug contributed to the hearing loss. Call your doctor right away if you suddenly lose your hearing while taking sildenafil, sometimes with ringing in your ears or dizziness. Do not take any additional dosages of sildenafil (Viagra) or comparable drugs like tadalafil (Cialis) or vardenafil (Levitra) until you have spoken with your doctor if you are taking sildenafil (Viagra) for erectile dysfunction.

Other usage of sildenafil

The signs of pulmonary arterial hypertension can also be treated with sildenafil in both men and women. This particular form of elevated blood pressure develops between the heart and the lungs. The heart has to work harder to pump adequate blood into the lungs when pulmonary hypertension develops. In order to relax the blood arteries, sildenafil acts on the PDE5 enzyme and inhibits its action in the lungs. By doing this, the blood flow to the lungs will be increased and the heart’s strain will be decreased.


Sildenafil  medications used to treat erectile dysfunction were first designed to treat high blood pressure. Millions of men and more recently those with pulmonary arterial hypertension, have had life-changing effects from sildenafil. Its position in the pharmaceutical industry has been cemented by its mode of action, potency and comparatively low level of safety. Although sildenafil has certain possible risks and adverse effects, its effectiveness in treating erectile dysfunction and other diseases cannot be disputed. For people in need of sildenafil’s therapeutic effects, the future of the drug appears bright as research and accessibility both advance. However, it’s crucial to keep in mind that sildenafil requires a prescription and should only be used in accordance with the advice of a trained medical practitioner.


Kokou Adzo is the editor and author of He is passionate about business and tech, and brings you the latest Startup news and information. He graduated from university of Siena (Italy) and Rennes (France) in Communications and Political Science with a Master's Degree. He manages the editorial operations at

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